The SNCA gene is also widely recognized as the primary causal factor in the early development of familial PD [64], and its involvement in PD is strongly supported by the facts that aggregated SNCA is the primary component of LB in sporadic PD, and missense and copy number variations in the SNCA gene are known to induce hereditary PD [65]. The gene discussed is SNCA; the disease is Parkinson disease.