After western diet feeding for 3 weeks, knockdown of Srebf2 only in C57BL/6J mice, rather than in LDLR‐deficient mice, led to a significantly decreased VLDL secretion rate (Figure 2C,D), suggesting that other lipid‐lowering pathways controlled by SREBP2 are involved in mice lacking LDLR upon WD feeding. The gene discussed is SREBF2; the disease is Wilson disease.