IRS2 and polycystic ovary syndrome: Goodarzi et al.10 reported that among the genes of the insulin signaling pathway including AKT2, INSR, IRS1, IRS2, GSK3B, PTP1B, PPP1R3, and SORBS1, the most influential ones on PCOS were INSR and ISR2. The INSR gene was addressed to the chromosomal position 19p13.3-13.2 with 22 exons and consists of two subunits: an α-subunit which is encoded by 1-11 exons and a β-subunit which is encoded by 12-22 exons.