KEGG pathway enrichment analysis by DAVID revealed that the top 20 pathways in which the differentially expressed proteins were enriched were glutathione metabolism, the phosphotransferase system (PTS), Epstein‒Barr virus infection, the MAPK signaling pathway, the phospholipase D signaling pathway, thyroid hormone synthesis, hypertrophic cardiomyopathy (HCM), the ErbB signaling pathway, long-term depression, the P53 signaling pathway, and the Jak-STAT signaling pathway (FDR-adjusted P < 0.05) (Fig. 4B). This evidence concerns the gene TP53 and hypertrophic cardiomyopathy.