IgE-binding activity is often assessed to predictsensitization,as most food allergies are IgE-mediated50 leading to immediate symptoms like urticaria, anaphylaxis, or oralallergy syndrome within 2 h of exposure.2,8 Specific forms,such as food-dependent exercise-induced anaphylaxis (FDEIA), alsofall under this category and often result in acute, severe reactions.2,8 IgE-mediated allergies occur when the immune system loses toleranceto benign food antigens, producing specific IgE antibodies duringinitial sensitization. The gene discussed is IGHE; the disease is allergic disease.