IGHE and Allergy: These antibodies bind to high-affinity receptorson mast cells and basophils, which release histamine and other mediatorsupon re-exposure, triggering allergic symptoms.3 Normally, oral tolerance suppresses IgE production,51 but disruptions in this process lead to sensitizationof mast cells and basophils.47 IgE-mediatedfood allergies can cause immediate symptoms after consuming allergenslike eggs, milk, wheat, crustaceans, or peanuts.