The childhood onset group had more atopic comorbidities including atopic dermatitis 32.6% (p = 0.001) and allergic rhinitis 63.9% (p = 0.001) as well as higher total blood IgE levels 150 KU/L (p = 7.8 × 10−8) compared to both later onset groups (Table 2). Here, IGHE is linked to allergic rhinitis.