First, the study was a single-center cross-sectional study, and there is a disproportion in number of cases with and without retinopathy, in addition, we did not compare the CRP/HDL-C ratio with other known biomarkers (e.g., PTX3) enables a more comprehensive assessment of its predictive value, so it is indispensable to future validate by expanding the sample size and including multicenter data to improve the generalizability and reliability of our findings. Here, PTX3 is linked to retinal disorder.