CRP and type 2 diabetes mellitus: Similarly, our study confirmed the CRP/HDL-C ratio good diagnostic value in assessing the risk of DR occurrence with an area under the ROC curve of 0.752, also suggested that elevated CRP/HDL-C levels are connected with a higher risk of DR, and changes of this composite indicator should be emphasized in clinical care, especially in T2DM patients with CRP/HDL-C higher than 3.734.