After release from the gel, Gelatinase-cleavable peptide Pro-Val-Gly-Leu-Iso-Gly (PVGLIG) can be degraded by MMP2/9 in tumor tissue, which induced the aggregation of NPs, effectively taken up by cancer cells [15], improved GA concentration in tumor cells and enhanced the antitumor effect of GA. The gene discussed is MMP2; the disease is neoplasm.