One-way logistic regression analysis showed that IL-6 (OR: 1.02, 95% CI: 1.01–1.03; p = 0.001), hs-CRP (OR: 1.59, 95% CI: 1.02–2.47; p = 0.041), and Plt (OR: 1.01, 95% CI: 1.01–1.02; p = 0.031) were important factors affecting the prognosis of ECMO-related nosocomial infections. The gene discussed is IL6; the disease is nosocomial infection.