It has been found that when IL-6 exceeds 150 pg./mL, the mortality rate increases significantly (Smieszek et al., 2021); in this study IL-6 expression levels in the ECMO-associated nosocomial infections surviving and non-surviving groups were IL-6 (40.62, 108.02 vs. 196.75, 1089.17ug/mL, p < 0.001), respectively, and one-way logistic regression analysis IL-6 (OR:1.02, 95% CI: 1.01 ~ 1.03; p = 0.001) was obtained, and the results suggest that serum IL-6 levels may be useful in assessing disease progression. Here, IL6 is linked to nosocomial infection.