Key genetic drivers of neuroblastoma include MYCN amplification, anaplastic lymphoma kinase (ALK) mutations or amplifications, telomerase reverse transcriptase (TERT) rearrangements, alpha-thalassemia/mental retardation X-linked (ATRX) deletions or mutations, and segmental chromosomal aberrations (SCAs). The gene discussed is MYCN; the disease is neuroblastoma.