Tumor cells secrete transforming growth factor β (TGF-β), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and white blood cell interleukin (IL) and other cytokines, which promote the transformation of NFs, epithelial cells, endothelial cells, bone marrow stem cells, fat stem cells, and pericytes into CAFs (6). This evidence concerns the gene TGFB1 and neoplasm.