The objectives of this study are to estimate the prevalence of EGFR gene mutation in adenocarcinoma of the lung at a tertiary care center in India using amplification-refractory mutation system polymerase chain reaction (ARMS-PCR) analysis and to analyze the correlation between EGFR gene mutations and clinical parameters, including age, gender, smoking history, disease stage, and ECOG performance status. Here, EGFR is linked to adenocarcinoma.