PIK3CA and adenocarcinoma: Colorectal SRCC was a rare histological subtype of adenocarcinoma, frequently associated with mutations in genes such as TP53, ARID1A, and APC (6) However, certain studies suggested that patients with colorectal SRCC had lower mutation rates in KRAS, PIK3CA, and APC compared to those with colorectal adenocarcinoma (7).