Research has shown that TRIB3 promotes RCC progression by upregulating the lipid droplet-associated protein PLIN2. Silencing TRIB3 expression in RCC cells significantly reduces lipid droplet (LD) accumulation and enhances apoptosis related to endoplasmic reticulum (ER) stress, thereby inhibiting tumor growth and metastasis (Li et al., 2024). Here, PLIN2 is linked to renal cell carcinoma.