INS and steatosis: It decreases gluconeogenesis and steatosis in the liver, slows gastric emptying, reduces gastrointestinal motility in the intestine, reduces food intake, modifies reward behavior, influences palatability in the brain, enhances insulin sensitivity, promotes glucose uptake in muscle, boosts insulin secretion, supports insulin synthesis and beta cell survival, diminishes apoptosis, and limits glucagon secretion in the pancreas [18].