Furthermore, X2K (eXpression2Kinases) analysis (Clarke et al., 2018) of UP DEGs in AA prostate cancer samples showed enrichment of EZH2 and SUZ12 transcription factors which are elements of PRC2 complex (Margueron & Reinberg, 2011) (Fig. 3). This evidence concerns the gene UPP1 and Familial prostate cancer.