A total of 18 polymorphisms were identified, of which, 9 polymorphisms were associated with asthma risk in overall populations: (IL-13 +2044 G/A, ADAM33 F+1, IL-4 -590C/T, ADAM33 T2, ADAM33 ST+4, ADAM33 T1, ORMDL3 rs7216389, VDR TaqI, and VDR FokI) 7. This evidence concerns the gene ORMDL3 and asthma.