For example, the rAd.sT.GM + anti-CTLA-4 treatment, which also impressively inhibited tumor progression and metastasis as shown early, only significantly reduced the production of IL-1β, IL-10, and IL-30 that was related to immunosuppression, but did not increase the expression levels of any stimulating Th1 cytokine we tested. This evidence concerns the gene CTLA4 and neoplasm.