Our findings indicate that rAd.sT.GM, which co-expresses sTGFβRIIFc and GM-CSF, effectively inhibits tumor growth and reduces metastasis in TNBC models, compared with other control adenoviruses which do not express sTGFβRIIFc and GM-CSF together, or any of them. The gene discussed is CSF2; the disease is neoplasm.