Studies have shown that extracellular vesicles (PE-EVs) from preeclamptic patients with pulmonary embolism can increase the expression of gene markers related to M1-type macrophages and decrease the expression of the M2-type macrophage marker CD163, indicating that PE-EVs may affect the development of pulmonary embolism by regulating macrophage polarization. This evidence concerns the gene CD163 and pulmonary embolism.