This continuum depicted in aged SGs strikingly mirrors the transition from NK cells (CD49b−CD49a−) to intermediate ILC1s (CD49b+CD49a+) and to ILC1s (CD49b−CD49a+) in the tumor microenvironment,19 hinting at a unified adaptation strategy of Group 1 ILCs in aging and cancer, two different scenarios united by gradual timelines of cellular and molecular damage accumulation. Here, ITGA2 is linked to cancer.