Our study revealed that the tumor markers and immunohistochemical factors in the observation group were closer to the normal level after the three-drug combination treatment, and the corresponding CA152, CA125, TPS, HER-2, Ki-67 and EGFR were lower than those in the control group, evidencing the better efficacy of the three-drug combination than the two-drug combination. The gene discussed is MKI67; the disease is neoplasm.