Numerous previous studies reported that longer duration of T2DM for more than 10 to 15 years, had significant negative impact on QOL.17,21 The possible logistic reason explained by the previous studies in above context may be that the glycemic control tends to be worse with a longer duration of diabetes due to a deterioration in beta cell function and resultant decrease in insulin secretion leading to vicious cycle causing more worsening of glycemic control and metabolic dysregulation. The gene discussed is INS; the disease is type 2 diabetes mellitus.