Postoperative adjuvant chemotherapy is now considered one of the standard treatment modalities for breast cancer.5 Sentinel lymph node biopsy (SLNB) combined with breast-conserving surgery, as an emerging radical procedure, has been widely used in developed countries, but has rarely been reported in China.6-8 For this reason, the study explored the effects of SLNB combined with breast-conserving surgery on surgical-related indexes, serum tissue polypeptide antigen(TPA) level and recurrence rate in patients with early breast cancer. This evidence concerns the gene PLAT and breast cancer.