Literature indicates that treadmill training promotes neurovascular regeneration in the penumbra of cerebral ischemic by improving the basic fibroblast growth factor (bFGF)/caveolin-1 (Cav-1)/vascular endothelial growth factor(VEGF) pathway after ischemic stroke.7 For chronic stroke patients, the repetitive and intensive lower limb training provided by treadmills can help patients relearn sensorimotor skills and promote central nervous system remodeling. Here, VEGFA is linked to ischemic stroke.