Detecting tumor marker levels is an important means of diagnosing and evaluating the treatment effectiveness of NSCLC, and it has high patient acceptance and is easy to monitor dynamically.15 There are many types of serum tumor markers in NSCLC, among which NSE and CEA are commonly used indicators for NSCLC diagnosis, clinical efficacy, and prognosis evaluation. The gene discussed is ENO2; the disease is neoplasm.