Notably, HTRA1 from remote tumor-released sEVs was delivered to OPs in the bone marrow, and promoted the upregulation of matrix metalloproteinase 13 (MMP-13) in OPs, thus leading to the dislocation of hematopoietic stem cells and aggregation of CD41− granulocyte-monocyte progenitors (GMPs) (32). The gene discussed is HTRA1; the disease is neoplasm.