Several studies also identified associations between JAK-STAT pathway-related SNPs and rheumatic diseases; genetic variants of STAT4 and STAT3 were reported to be associated with susceptibility to axSpA (26–28), while SNPs of STAT4 and tyrosine kinase (TYK)2 may be associated with susceptibility to PsA (along with rheumatoid arthritis) (29). Here, STAT4 is linked to rheumatic disorder.