Some regulators, such as YTHDC2, YTHDF2, and FMR1 showed significant changes in the early stage of DKD, some regulators, such as YTHDC1 and METTL14 exhibited significant changes in the advanced stage of DKD, and some regulators, such as METTL3 demonstrated dynamic changes, which suggested that m6A regulators may play a role in the development of the DKD process. The gene discussed is YTHDF2; the disease is diabetic kidney disease.