ADAMTS14 is a subtype member of the ADAMTS (a disintegrin-like and metalloprotease domain with thrombospondin type 1 repeats) metalloproteinase family, which forms procollagen N-protease with ADAMTS2 and ADAMTS3 to degrade type I, II, III, and V procollagen and promote collagen fibers formation, and participate in coagulation processes, growth and evolution, signal transduction, and tumor progression (53, 54). This evidence concerns the gene ADAMTS2 and neoplasm.