Similarly, mutations in the gene encoding the Ca2+ release-activated Ca2+ (CRAC) channel, ORAI1, and its activator stromal interaction molecule 1 (STIM1), are implicated in severe combined immunodeficiency (SCID), tubular aggregate myopathy (TAM), and Stormorken syndrome [10,11]. The gene discussed is STIM1; the disease is severe combined immunodeficiency.