HMGB1 and epilepsy: Therefore, the detection of HMGB1 in cerebrospinal fluid can predict the cause and prognosis of epilepsy,11 whose prognostic value is confirmed since the examination of the receiver operating characteristic curve indicates that HMGB1 has a higher level of accuracy in predicting seizure frequency compared to interleukin‐1β (IL‐1β),12 indicating that HMGB1 may be a critical factor in the seizure mechanism.