At the base of primary cilia, ADGRV1 physically interacts with the components of the TRiC/CCT chaperonin complex and the three Bardet-Biedel syndrome (BBS) chaperonin-like proteins BBS6, BBS10 and BBS12 (Knapp et al., 2022; Linnert et al., 2023b). The gene discussed is MKKS; the disease is Bardet-Biedl syndrome.