ZC2HC1A and retinal degeneration: Interestingly, in our omics data on interacting proteins of ADGRV1 and DEGs in ADGRV1-deficient systems, we find additional links to molecules associated with further retinal ciliopathy: defects in CEP250 (atypical USH), FAM164a (RP28) or USH1C, PCDH15 (USH1F), WHRN (USH2D) (Ahmed et al., 2001; Karlstetter et al., 2014; Khateb et al., 2014; Sorusch et al., 2017; Grotz et al., 2022) all lead to photoreceptor cilia dysfunctions and retinal degenerations in humans and mice.