Literature indicates that the ITGA4 family plays a role in leukocyte recruitment during injury, infection, and inflammation, with applications in treatments for inflammatory bowel disease (Dotan et al., 2020; Tyler et al., 2022) and lupus nephritis (Ryu et al., 2024), and protection against non-alcoholic steatohepatitis (Rai et al., 2020). Here, ITGA4 is linked to metabolic dysfunction-associated steatohepatitis.