Ucp2 knock-out animals consistently demonstrate bLR-like behaviors, including decreased exploration, and anxiety- and depressive-like behaviors, especially following stress (Andrews et al., 2006; Du et al., 2016; Gimsa et al., 2011; Hermes et al., 2016; Sun et al., 2011; Wang et al., 2014; Yasumoto et al., 2021). Here, UCP2 is linked to Anxiety.