MFGE8 and stress-related disorder: bHR-like animals also had upregulation of protective Mfge8 (Liu et al., 2014) and upregulation of Nqo2, which can enhance reactive oxygen species production or reduce oxidative stress (Janda et al., 2015; Rashid et al., 2021; Vella et al., 2005) in a manner important for encoding novelty in hippocampal interneurons (Gould et al., 2020) and potentially stress-related disorders (Bainomugisa et al., 2021).