UCP2 and psychiatric disorder: Human GWAS also link UCP2, SPG7, and WDR93 to the stress response, psychiatric disorders, externalizing behavior, and substance use disorders (Karlsson Linnér et al., 2021; Li et al., 2022; Orhan et al., 2012; Pehlivan et al., 2020; Rimpelä et al., 2019; Russell et al., 2020; Saunders et al., 2022; Yasuno et al., 2007).