NMO‐IgG has been shown to modulate AQP4 and EAAT‐2 expression via astrocytic FcγR‐mediated internalization of the AQP4/NMO‐IgG complex as well as astrocytic IL‐6 expression (Hinson et al. 2017). The gene discussed is AQP4; the disease is neuromyelitis optica.