METTL3 and cancer: Gene Set Enrichment Analysis (GSEA) showed that MYC targets, mitotic spindle, G2M checkpoint, and glycolysis, all of which are hallmarks of cancer cells [29, 30, 31, 32], were significantly activated in the Mettl3 cKO group (Fig. 3A), confirming accelerated tumorigenesis after hepatic METTL3 knockout.