Transcriptional super‐enhancers have been shown to play critical roles in the overexpression of critical oncogenes, such as the MYCN oncogene in MYCN‐amplified neuroblastoma[5, 6] and MYC oncogene in multiple myeloma and leukemia.[2, 4] In this study, through analyzing publicly available histone H3K27 acetylation ChIP sequencing datasets, we have identified super‐enhancers at the PRKCQ‐AS1 gene locus in MYCN nonamplified, but not in MYCN‐amplified, neuroblastoma cell lines. Here, PRKCQ-AS1 is linked to AL amyloidosis.