Importantly, while PRKCQ‐AS1 or MSI2 overexpression augments MYCN nonamplified neuroblastoma cell proliferation, MSI2 knockdown reverses PRKCQ‐AS1‐induced neuroblastoma cell proliferation, and PRKCQ‐AS1 knockdown blocks MSI2‐mediated neuroblastoma cell proliferation. This evidence concerns the gene PRKCQ and neuroblastoma.