HLA-G and neoplasm: Studies [107, 108, 109, 110, 111] have shown that 3‐HAA can suppress nitric oxide (NO) production in macrophages, thereby reducing their tumor‐killing function, inducing apoptosis in cytotoxic T cells and Th1 cells, weakening immune‐mediated tumor destruction, and enhancing tumor immunosuppression by modulating HLA‐G expression on dendritic cells and promoting Treg cell differentiation.