The reduction of miR-671–5p in EVs from menstrual blood-derived stem cells is responsible for the positive regulation of NF-kB [80] or that EVs deriving from senescent cells and enriched in miR-30b-5p induce IL-1β and IL-6 interleukins with concomitant activation of NF-kB pathways [81], or that EVs shuttling miR-660 promote breast cancer progression through a KLHL21-mediated IKKβ/NF-kB p65 axis [82] are other observations in line with an RNA-induced effect in EV recipient cells. This evidence concerns the gene KLHL21 and breast cancer.