To investigate how ZBTB24 deficiency may lead to increased susceptibility to mycobacterial infections, we mined differentially methylated genes in ICF2 patients for genes known to cause MSMD or monogenic tuberculosis when mutated [47] using publicly available data from Velasco et al. (NCBI GEO database, accession GSE95040) [17, 48]. Here, ZBTB24 is linked to Mendelian susceptibility to mycobacterial diseases.