Furthermore, IHC analysis of a glioma tissue microarray indicated that higher PHGDH levels in high-grade gliomas compared to low-grade ones, and patients with high PHGDH IHC scores were more prone to recurrence and had lower survival rates (Fig. 1L-N, Supplementary Figure S2J and Supplementary Table 1). This evidence concerns the gene PHGDH and central nervous system cancer.