In type 2 diabetes mellitus (T2DM) rat models, BXD regulated blood glucose homeostasis by altering serum bile acid metabolism profiles, upregulating farnesoid X receptor (FXR) expression, and modulating the secretion of serum and pancreatic glucagon-like peptide-1 (GLP-1) [123]. The gene discussed is NR1H4; the disease is diabetes mellitus.