However, the abundance of immune cell infiltration in SLE was different, with 10 immune cells (activated CD4 T cell, activated dendritic cell, central memory CD8 T cell, eosinophil, immature dendritic cell, macrophage, mast cell, MDSC, neutrophile and plasmacytoid dendritic cell) increased significantly in SLE, whereas 7 immune cells (activated CD8 T cell, CD56 dim natural killer cell, effector memory CD4 T cell, effector memory CD8 T cell, nature killer T cell, type 17 T helper cell and type 2 T helper cell) decreased significantly in SLE (Supplementary Fig. 4A, 3B). The gene discussed is CD4; the disease is systemic lupus erythematosus.