CD4 and atrial fibrillation: As shown in Supplementary Fig. 3A, B, the scores of immune cell contents were higher in most AF groups, with 17 immune cells (activated CD4 T cell, activated dendritic cell, central memory CD4 T cell, central memory CD8 T cell, effector memory CD4 T cell, effector memory CD8 T cell, immature B cell, immature dendritic cell, macrophage, mast cell, MDSC, memory B cell, monocyte, natural killer cell, neutrophile, regulatory T cell and type 1 T helper cell) were significantly increased in AF groups.