The mediation proportion of 7.14% shows that this pathway accounts for 1 in 14 preventable cases, analogous to the proportion of influenza protection mediated by CD8+ T cells [53].While the confidence interval approximating zero (-0.061 to -0.000) necessitates cautious interpretation, the negative directional trend of the point estimate corresponds with established gut-immune axis mechanisms [54]. This evidence concerns the gene CD8A and influenza.