In renal cell carcinoma cells, it has been shown that HIF-1 accumulation leads to downregulation of pseudouridine synthase 10 (PUS10) (Luo et al. 2023), an enzyme responsible for converting uridine to pseudouridine (Ψ) in tRNA (Gurha and Gupta 2008). This evidence concerns the gene PUS10 and hereditary clear cell renal cell carcinoma.