METTL14-induced ferroptosis, mediated through m6A-YTHDF2-dependent degradation of solute carrier family 7 member 11 (SLC7A11), is dramatically abolished in hypoxic environment in a HIF-1α-dependent manner, contributing to HCC progression (Fan et al. 2021). The gene discussed is HIF1A; the disease is hepatocellular carcinoma.