HK2 and ovarian carcinoma: WTAP, a key subunit of the m6A methyltransferase complex, is upregulated by HIF-1α in ovarian cancer, where it promotes the Warburg effect by stabilizing the mRNA of the glycolytic enzyme hexokinase 2 (HK2) through miR-200 in an m6A-dependent manner, thereby accelerating tumor progression under hypoxic conditions (Lyu et al. 2022).