HIF1A and ovarian carcinoma: More recently, another study demonstrated that in ovarian cancer, HIF-1α-driven upregulation of ALKBH5 stimulates downstream focal adhesion kinase (FAK)/Src proto-oncogene (Src) signaling and boosts integrin subunit beta 1 (ITGB1) expression by disrupting the YTHDF2 protein-mediated m6A degradation pathway, ultimately promoting lymph node metastasis and lymphangiogenesis (Sun et al. 2023).