Currently, several ApoE memetic peptides have been developed and investigated in brain diseases clinically and experimentally, such as CN‐105, COG112, and COG1410 etc. There was evidence that these ApoE memetic peptides exerted anti‐neuroinflammation, antiexcitotoxic and neuroprotective effects in translational models of CNS disorders [5, 6, 7, 8, 9, 10]. Here, APOE is linked to brain disorder.