Further supporting the translational relevance of our mouse model to psychiatric and neurodevelopmental disorders, our study identified a transcriptional downregulation of several genes implicated in schizophrenia and ASD, including Setd1a [62–64], Cacna1g [64, 67], Ank3 [68], Shank1 [69, 70], and Shank3 [69, 70], in mice expressing HERV-W ENV. Here, SHANK1 is linked to neurodevelopmental disorder.