In addition to including members of the Set1-like H3K4 methyltransferase family (Kmt2a, Kmt2b, Kmt2c, and Kmt2d), these modules also encompassed rare variant genes associated with schizophrenia and ASD (Setd1a, Cacna1g, Ank3, Shank1, and Shank3; Fig. 2C). Here, SHANK3 is linked to schizophrenia.