SHANK3 and schizophrenia: Consistent with our findings, ORY-1001 has also been shown to restore H3K4me2 levels in the brains of Shank3-deficient and Setd1a-deficient mice [41, 42], suggesting that normalization of reduced H3K4me2 levels may be a key mechanism by which ORY-1001 alleviates ASD- and schizophrenia-related dysfunctions.