Murine GL261 glioma cells were transduced with a lentiviral vector encoding human HER2 to enable further testing of the NK-92/5.28.z cell product currently under clinical investigation in the CAR2BRAIN trial in in vivo experiments in the syngeneic C57BL/6 mouse model [22, 32] [Fig. 1a]. The gene discussed is ERBB2; the disease is central nervous system cancer.