SETD6 and Familial prostate cancer: Indeed, publicly available subcellular localization data from the Human Protein Atlas (https://www.proteinatlas.org/) show that SETD6 localizes to the nucleoplasm in human embryonic kidney (HEK293T), prostate cancer (PC-3) and osteosarcoma (U2OS) cells; in addition, SETD6 is present in the cytosol of the latter two cell lines.