Furthermore, the levels of RELA-K310me1 at the promoters of RELA target genes (IL8, IL1A, MYC and CCND1) decreased upon depletion of SETD6 in U2OS and acute monocytic leukemia cells (THP-1), and it was also shown that SETD6 represses RELA transactivation activity in U2OS, THP-1 and primary mouse bone-marrow-derived macrophage (mBMDM) cells. The gene discussed is SETD6; the disease is acute monocytic leukemia.