For the SETD2_Y1666 mutation, Y1666 is in the SET domain of SETD2, which is the catalytic domain mediating H3K36me3-specific methyltransferase activity.52 SETD2_Y1666 targeted by ABEmax could generate the Y1666C mutation, a reported mutation from both COSMIC (Catalogue of Somatic Mutations in Cancer) and ICGC database (Fig. 5b). The gene discussed is SETD2; the disease is cancer.