Conversely, one mutant, MAPK3_Y333, was found to downregulate HLA-I expression and upregulate PD-L1 expression and render A375 cells to be more resistant to T cell killing (Fig. 2c; Fig. 4d; Supplementary Fig. 7i), indicating its potential role in promoting tumor evasion. The gene discussed is CD274; the disease is neoplasm.