MEN1 and acute myeloid leukemia: Consistent with the possibility that the loss of occupancy at NF-Y motifs abrogates menin/MLL binding to chromatin, more than half (614 out of 1,127, 54.5%) of the sites that lost accessibility by MMF were menin binding sites in MLL-AF9-induced AML cells, while only 6.5% (875 out of 13,398) of the sites that increased accessibility by MMF are bound by menin (Fig. 6k).