Consistent with previous findings that LSCs demonstrate elevated levels of amino acids13, we found that MLL-AF9-driven LSCs exhibit a higher abundance of metabolites enriched in gene ontology (GO) terms such as aminoacyl-tRNA biosynthesis, arginine metabolism, and glycine, serine, and threonine metabolism when compared to GMP and bulk AML cells (Supplementary Fig. 1d–g). The gene discussed is MLLT3; the disease is acute myeloid leukemia.