KMT2A and acute myeloid leukemia: To uncover the metabolic landscape of the immature fraction of AML, we compared the metabolic profiles of leukemic granulocyte-macrophage progenitors (L-GMPs)19 and bulk AML cells derived from an MLL-AF9-driven murine AML model, with normal GMPs and whole bone marrow (WBM) cells from C57BL/6 mice using liquid chromatography-mass spectrometry20 (Fig. 1a).